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Vivo X50e 5G has been launched in Taiwan. The 5G smartphone joins the company’s X50 series of phones that includes the Vivo X50 and the Vivo X50 Pro, both of which are available for purchase in India. The mid-range Vivo X50e 5G is powered by the Qualcomm Snapdragon 765G SoC and features a 6.44-inch AMOLED display. It features a quad rear camera setup that includes a 48-megapixel primary shooter. The phone packs a 4,350mAh battery with support for 33W fast charging.

Vivo X50e 5G price

The smartphone is listed on the company’s Taiwan website in a single 8GB + 128GB storage configuration. It comes in two colour options – Night and Water Mirror. Although the listing doesn’t mention a price, reports by Gizmochina and MySmartPrice claim that the phone is priced at TWD 13,990 (roughly Rs. 35,600). There is no information on whether the smartphone will make its way to India.

Vivo X50e 5G specifications

The dual-SIM (Nano) Vivo X50e 5G runs on Funtouch OS 10, based on Android 10. It features a 6.44-inch full-HD+ AMOLED display (1,080×2,400 pixels) with a waterdrop-style notch. Under the hood, the new Vivo smartphone is powered by the Qualcomm Snapdragon 765G SoC, paired with 8GB of RAM and 128GB of inbuilt storage that can be expanded via a microSD card.

For photos and videos, the Vivo X50e 5G comes with a quad rear camera setup that comprises a 48-megapixel primary shooter with f/1.79 aperture, a 13-megapixel shooter with f/2.46 aperture, an 8-megapixel sensor with an f/2.2 wide angle lens, and a 2-megapixel sensor with a f/2.4 macro lens. The cameras are placed inside a diamond-shaped module. For selfies and video calls, the phone sports a 32-megapixel shooter with f/2.0 aperture. The smartphone comes with several photo modes, including super moon, super night scene, portrait, HDR backlight, and macro.

The Vivo X50e 5G packs a 4,350 mAh battery with support for 33W Flash Charge fast charging. There’s also a 3.5mm headphone jack and NFC support. Other connectivity options include Wi-Fi 5, Bluetooth 5.1, and a USB Type-C port. It comes with an under-display fingerprint sensor.

 


Which is the bestselling Vivo smartphone in India? Why has Vivo not been making premium phones? We interviewed Vivo’s director of brand strategy Nipun Marya to find out, and to talk about the company’s strategy in India going forward. We discussed this on Orbital, our weekly technology podcast, which you can subscribe to via Apple Podcasts or RSS, download the episode, or just hit the play button below.

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Targeting Aging is the Way to Treat Diseases of Aging

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Near all work to date on the treatment of age-related disease has failed to consider or target underlying mechanisms of aging, the molecular damage that accumulates to cause pathology. It has instead involved one or another attempt to manipulate the complicated, disrrayed state of cellular metabolism in late stage disease, chasing proximate causes of pathology that are far downstream of the mechanisms of aging. This strategy has largely failed, and where it has succeeded has produced only modest benefits. Consider that statins, widely thought to be a major success in modern medicine, do no more than somewhat reduce and delay mortality due to atherosclerosis. They are not a cure. The mechanisms of aging are why age-related diseases such as atherosclerosis exist. They are the root cause of these diseases. Attempted therapies that continue to fail to target the mechanisms of aging will continue to fail to deliver meaningful benefits to patients. This must change.

Targeting Aging is the Way to Treat Diseases of Aging

Image credit: Pixabay (Free Pixabay license)

Aging doesn’t kill people – diseases kill people. Right? In today’s world, and in a country like the United States, most people die of diseases such as heart attack and stroke, cancer, and Alzheimer’s. These diseases tend to be complex, challenging, difficult, and extremely ugly to experience. And they are by nature chronic, caused by multifactorial triggers and predispositions and lifestyle choices. What we are only now beginning to understand is that the diseases that ultimately kill us are inseparable from the aging process itself. Aging is the root cause. This means that studying these diseases without taking aging into account could be dangerously misleading … and worst of all, impede real progress.

Take Alzheimer’s disease. To truly treat a disease like Alzheimer’s, we would need to identify and understand the biological targets and mechanisms that trigger the beginning of the disease, allowing us to intervene early – ideally, long before the onset of disease, to prevent any symptoms from happening. But in the case of diseases like Alzheimer’s, the huge problem is that we actually understand very little about those early targets and mechanisms. The biology underlying such diseases is incredibly complex. We aren’t sure what the cause is, we know for sure there isn’t only one target to hit, and all prior attempts to hit any targets at all have failed. When you start to think about how much of what we think we know about Alzheimer’s comes from very broken models – for example, mice, which don’t get Alzheimer’s naturally – it becomes totally obvious why we’re at a scientific stalemate in developing treatments for the disease, and that we’ve likely been coming at this from the wrong direction entirely.

The biggest risk factor for Alzheimer’s isn’t your APOE status; it’s your age. People in their twenties don’t get Alzheimer’s. But after you hit the age of 65, your risk of Alzheimer’s doubles every five years, with your risk reaching nearly one out of three by the time you’re 85. What if going after this one biggest risk factor is the best vector of attack? Maybe even the only way to truly address it? This isn’t about the vanity of staying younger, about holding on to your good looks or your ability to run an 8 minute mile. It’s about the only concrete possibility we have to cure these diseases. Instead of choosing targets for a single specific disease, i.e. a specific condition that arises in conjunction with aging, we can get out in front of disease by choosing targets that promote health. And we can identify these by looking at disease through the lens of the biology of aging.

Link: https://a16z.com/2020/10/07/aging-alzheimers-drug-discovery/

Source: Fight Aging!




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The Mandalorian Season 1 Recap Distills the Star Wars Series Into 89 Seconds

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Before The Mandalorian season 2 premieres Friday afternoon on Disney+ Hotstar (and Friday midnight on Disney+ in the US), Disney and Lucasfilm have given us an official 89-second recap of The Mandalorian season 1. That’s very brief, but it speaks to the fact that The Mandalorian wasn’t a narratively-heavy show on its debut last year.

Everything You Need to Know About The Mandalorian Season 2

The Mandalorian season 1 recap touches upon Mando’s (Pedro Pascal) profession (he’s a bounty hunter), his newest target (Baby Yoda), the people he meets along the way — Cara Dune (Gina Carano), Greef Karga (Carl Weathers), and Kuiil (voiced by Nick Nolte) — and the consequences of his decision to bring Baby Yoda under his wing.

“You have something I want. It means more to me than you will ever know,” the darksaber-wielding villain Moff Gideon (Giancarlo Esposito) says deep into The Mandalorian season 1 recap, as we are given a reminder of the Star Wars series’ action-heavy side. Gideon then declares: “It will be mine.”

The season 1 recap wraps by setting up The Mandalorian season 2, as tribe leader The Armorer (Emily Swallow) instructs Mando to reunite Baby Yoda “with its own kind”. Mando wonders: “You expect me to search the galaxy for the home of this creature?” Well, yes, otherwise what would we do in season 2, Mando.

In addition to Pascal, Carano, Weathers, and Esposito, The Mandalorian season 2 also stars Omid Abtahi as Dr. Pershing, Horatio Sanz as Mythrol, Rosario Dawson as Ahsoka Tano, Katee Sackhoff as Bo-Katan Kryze, Temuera Morrison as Boba Fett, Timothy Olyphant as former slave Cobb Vanth, Michael Biehn as a rival bounty hunter, and Sasha Banks in an undisclosed role.

Jon Favreau (The Lion King, Iron Man) created The Mandalorian and serves as showrunner and head writer on the Star Wars series. Favreau and Weathers are among the directors on season 2 alongside Dave Filoni, Rick Famuyiwa, Bryce Dallas Howard, Peyton Reed, and Robert Rodriguez.

The Mandalorian season 2 premieres October 30 on Disney+ Hotstar in India. Episodes will air weekly.

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Wild West for developers when it comes to writing cloud-native apps

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Commentary: Containers ate your infrastructure, but what comes next at the application layer? A new survey points to big, industry-wide decisions to be made about the tech used to write applications.

Image: vladans, Getty Images/iStockphoto

Twenty years ago it seemed certain that the underpinnings of future data center infrastructure would be Linux clusters running on x86 “commodity” hardware. We just didn’t know what to call it or where exactly it would run.

The big systems vendors like IBM, Sun, HP, and Cisco weren’t calling it “cloud”; instead, the vendors named it utility computing, autonomic computing, grid computing, on-demand, and n- other terms. At Comdex 2003, it was reported on ZDNet that “participants in a panel discussion at Comdex agree that utility computing is more like a river than a rock, but have little luck nailing down a real definition.” (ZDNet is a sister site of TechRepublic.)

Two decades later we know what to call it (“cloud”), and we know it’s built with containers and a whole lot of Linux. As detailed in the new Lightbend survey Cloud Native Adoption Trends 2020-2021, 75.2% of respondents already host the majority of their applications in some sort of cloud infrastructure, and roughly 60% run most of their new applications in Kubernetes/containers.

Now we’re faced with another major rethink that will affect tens of millions of developers operating at the application layer, where there are common threads on crucial concepts, but everyone is bringing different and predictions for the future.

SEE: Top 5 programming languages for systems admins to learn (free PDF) (TechRepublic)  

Higher up the stack

We’ve all felt this happening as containers have eaten into the virtual machine landscape, as web programming languages (JavaScript) surpass JVM/server-side languages (Java) in developer popularity, and as serverless, JAMstack, and other still-being-named phenomena change the “developer experience” in writing cloud-native applications. The diversity of choice in the “right way” to write software for the cloud has become a bit of a Wild West for developers.

As Google developer advocate Kelsey Hightower put it earlier this year, “There’s a ton of effort attempting to ‘modernize’ applications at the infrastructure layer, but without equal investment at the application layer, think frameworks and application servers, we’re only solving half the problem.”

“There’s a huge gap between the infrastructure and building a full application,” said Jonas Bonér, CTO and co-founder at Lightbend, in an interview. “It’s an exercise for the programmer to fill in this huge gap of what it actually means to provide SLAs to the business, all the things that are hard in distributed systems but needed for the application layer to make the most of Kubernetes and its system of tools.”

SEE: Top cloud trends for 2021: Forrester predicts spike in cloud-native tech, public cloud, and more (TechRepublic)

Lightbend’s cloud adoption report highlights some of these major decision points that remain murky for the application layer of the cloud-native stack.

“Building cloud-native applications means creating software that is designed with the advantages—and disadvantages—of the cloud in mind,” said Klint Finley, author of the Lightbend survey. “It means taking advantage of the fact that it’s possible to outsource entire categories of functionality—like databases and authentication—to public cloud services and planning for the fact that communication between those cloud components might be unreliable.”

Some developers still prefer frameworks they personally maintain and scale, while the business side clearly prefers frameworks that are delivered “as a service” via API, the survey says. Namely, 54.7% of managers said it was their highest priority to write business applications that specifically leverage the underlying cloud infrastructure vs. 38.3% of developers. Meanwhile, consuming back-end services by API rather than building and maintaining your own is the defining characteristic of the emergent JAMstack (JavaScript / API / Markup) architecture that has the weight of Facebooks’ React programming language momentum behind it. But it’s a completely different approach than the old-school server-side mindset for Java developers that still rule the roost and command vast legacy systems at most major enterprises.

The survey also suggests that developers think about cloud computing more in terms of specific technologies like Kubernetes and containers, while management thinks of cloud computing more as a new way to build applications. Management tends to prefer outsourcing as much maintenance as possible, while developers’ preference for configurability over automation reveals a desire not to lose too much control over the many layers of an application stack. As one respondent put it: “SaaS comes with ease of adoption and faster time to market, however many do not understand the cost of running them at scale.”

Disclosure: I work for AWS, but the views expressed herein are mine.

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