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People love discussing potential harms and benefits of cannabis. It is primarily a recreational drug and there is no other way around – most people use it for pleasure. However, that is not to say that there are no benefits. Non-psychoactive substance cannabidiol (CBD) does help reducing inflammation, but it could also be useful in treating anxiety, Alzheimer’s disease, PTSD and some other conditions. Why?

A new UCL-led study showed that CBD improves  blood flow to the hippocampus.

Cannabidiol does improve blood flow in your brain

Cannabidiol (CBD) could help treating anxiety, PTSD, Alzheimer’s and a bunch of other conditions that involve a reduced blood flow in the brain. Image credit: Cannabis Pictures via Wikimedia (CC BY 2.0)

Reduced blood flow in the brain has been cited as one of the reasons why some people develop some cognitive or memory problems. It is also a factor in anxiety disorder and PTSD. And people have been saying that CBD helped them a lot to cope with these conditions. Cannabidiol is not psychoactive, which makes it an acceptable product even for those who really dislike the whole drug aspect of cannabis.

Scientists selected 15 young adult participants for this study. None of them had any significant cannabis use experience. Each participant was given a 600mg of oral CBD or a placebo at different times.

Obviously, participants didn’t know what they are getting and they had no way of knowing, because CBD doesn’t have that easily describable effect on one’s mood or emotional state. Then scientists measured blood flow to the hippocampus using a technique called ‘arterial spin labelling’. Essentially it is just a specialized MRI method to scan changes in the blood oxygen levels.

And scientists did find that CBD significantly increased blood flow in the hippocampus, even though a similar effect was not observed in the rest of the medial temporal lobe. Particularly, an increased blood flow was noticed in the orbitofrontal cortex, in the prefrontal cortex, which is used for planning and decision making.

Dr Michael Bloomfield, lead author of the study, commented results: “If replicated, these results could lead to further research across a range of conditions characterised by changes in how the brain processes memories, including Alzheimer’s disease, where there are defects in the control of blood control flow, along with schizophrenia and post-traumatic stress disorder”.

Scientists believe this to be the first study of its kind to find that CBD increases blood flow to key regions involved in memory processing. Further studies are needed, but this is a great beginning to something highly valuable to the entire human race. In essence, scientists could start developing CBD-based treatments for various mental conditions very soon.  Cannabidiol (CBD) could help treating anxiety, PTSD, Alzheimer’s and a bunch of other conditions that involve a reduced blood flow in the brain. Image credit:


Source: UCL

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PS5 restock: Here’s where and how to buy a PlayStation 5 this week

ps5 box console controller

It’s not too late to try to score a PlayStation 5 this week. Here’s where to look for the elusive PS5 in stores and online, as merchandise restocks arrive around on Sony direct and other sites.

Image: Sony Interactive Entertainment

If you’re still looking for a PS5 for a holiday gift or for yourself, there’s still a chance. I’m in the trenches with you, trying to nab one for my kid, and here’s where I’ve been searching and what I’m finding. I’ll update this article regularly as I find out more information.

Of course finding a PlayStation 5 has been a nightmare since it launched on Nov. 12. Retailers such as Walmart, Meijer, Target and Best Buy sold out fast. Bundles became the way to go, with GameStop, Antonline and Newegg offering bundles starting at $600-plus and even those sold out within an hour or less. 

For those new to the PS5 shopping game, there are two versions. There is a $400 digital-only model and a $500 console version. The only differences between the two are that the console edition includes an Ultra HD Blu-ray disc drive to allow for PS5 Blu-ray disc games and PS4 Blu-ray disc games, and video from 4K Ultra HD Blu-rays and standard Blu-rays and DVDs. The digital edition has been selling out faster than the console version, because of its lower price, but that’s if you count time in seconds. They’re both in great demand, and the goal for most people is to buy one at any reasonable price solo or in a bundle. There are scalpers afoot, but we won’t talk about them since that’s not an option I’m willing to consider. 

SEE: Guide to becoming a digital transformation champion (TechRepublic Premium)

Check websites regularly, use the refresh button

An important way to find a PS5 is to constantly check the main sites that sell the PS5, such as Target, Best Buy, Walmart, Kohl’s, Sam’s Club, Costco, Sony Direct, GameStop and Antonline, and refresh the page frequently. 

On Thursday morning, Target released stock of the PS5 online across the US, but the stock appears to have dried up. Antonline had a short-lived restock on Thursday afternoon, but it sold out fast. Costco also restocked the PS5 bundle, but it sold out, too. All of this means that there is PS5 stock out there and so refreshing and paying attention to retailer’s website is the way to go. 

Walmart Canada had PS5 units go on sale this morning, but they’ve also sold out. They were planning to sell the Xbox Series X today online with new stock, but sent out a Tweet that they were delaying that until further notice. 

<strong>PS5 problems: Trying to beat a bot, scammer or scalper and score a PlayStation 5</strong>


Best Buy often shows out of stock, but several times it’s given me an “Open Box” option for stock. It disappeared just as quickly, as others grabbed the available stock, but it was there. So someone nabbed one. The last time I saw this was Nov. 25, so it’s been a few days, but others have reported on social media that they’ve seen the same thing more recently.

Here are other places to look for a PS5 this week. Retailers such as GameStop have been offering bundles of a PS5 console or digital edition paired with controllers and games for around $800, and they sell out fast. Adorama released limited stock online Monday morning, but it sold out in four minutes. 

Remember to continue to look at Walmart periodically, too. And also Amazon. The retailer has been showing restocking, and sometimes it’s through third parties that are selling for scalped rates, but you might get lucky and find it for the regular retail price. 

You can use these direct links to go to the retailers’ pages for the PlayStation 5 digital edition and console version:

Best Buy: PS5 Console and the PS5 Digital Edition

Amazon: PS5 Console and the PS5 Digital Edition

GameStop: PS5 Console and the PS5 Digital Edition

Target: PS5 Console and the PS5 Digital Edition

Walmart: PS5 Console and the PS5 Digital Edition

Sony PS5 queue for direct purchasing

Buying a PS5 direct from Sony is a definite possibility as they restock periodically as well. A queue is formed when stock is available and it gives an approximate wait time and it will let you enter the purchase area once your time arrives. This actually happened once for me, and it told me my wait time would be more than an hour, but at the time the queue opened up, I had stepped away from my laptop and I missed my chance after being in a digital line for about 90 minutes. But this option does work, even if you’ve been waiting for a very long time as I had that day, so there’s hope. 


Image: Teena Maddox/TechRepublic

At 5 pm EST on Thursday, Sony opened up the queue again. I jumped on immediately, thanks to social media alerts. The first notice said I had more than an hour to wait, but within about 20 minutes, that changed to a 45-minute wait. And then, around 5:30, it said my wait was down to 17 minutes, then at 5:38 pm, down to 11 minutes. (No, the time doesn’t actually count down in an orderly fashion. It kind of jumps around.) The next Sony update, sadly, at 5:45 pm, said that they were out of stock. I did not score a PS5. I was so close.


Image: Teena Maddox/TechRepublic

Follow PS5 social media accounts

Another option is to use social media to your advantage. There are many social media accounts providing regular updates on which retailers are offering potential merchandise drops of the PS5. Employees who work at the stores are leaking information, and shoppers are showing receipts as they find in-store units. 

To take advantage of this source of information, find the social media accounts that you find trustworthy and follow them. A quick glance on Twitter has @spieltimes reporting Walmart walk-ins as a reputable source for PS5 units, as well as a possible PS5 queue opening up today on the PlayStation direct store online, and potential stock coming in at Target. And Canadian shoppers will have better luck at Walmart, according to @PS5StockUpdates, who accurately reported about the Walmart restock and other alerts.  

Whichever option you choose to try to score a PS5, know that you’re not alone. I’m there with you and will keep updating this article with any information I find that might help in everyone’s search.

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Photonics meets surface science in a cheap and accurate sensor for biological liquids

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Skoltech researchers and their colleagues from Russia and Israel have come up with a new, simple and inexpensive method of testing liquid biological samples that can be further developed to work in clinical settings, including real-time testing during surgery. The paper was published in the journal Light: Science & Applications.

Photonics meets surface science in a cheap and accurate sensor

Image credit: Pixabay (Free Pixabay license)

The most common method of real-time diagnostic testing for biological samples (such as urine or saliva) that is used in the healthcare system, optical label-free sensors, are highly sensitive, but that sensitivity comes at a cost in terms of time and resources. Looking for a more efficient alternative, the research team, coordinated by Prof. Dmitry Gorin from the Center for Photonics and Quantum Materials at the Skolkovo Institute of Science and Technology (Skoltech) and Dr. Roman Noskov from Tel Aviv University, turned to the data that these sensors normally disregard: optical dispersion of the refractive index of a sample that can act as a fingerprint of sorts for tracking the changes in its composition.

They introduced the concept of in-fiber multispectral optical sensing (IMOS) for liquid biological samples in both static and real-time modes. According to the team, this sensing method is precise, reliable and very sensitive to impurities in the sample, which can make it useful both for diagnostic purposes and for real-time simulations of various biological processes.

Hollow-core microstructured optical fiber (HC-MOF), a particular kind of optical fibers which confine light inside a hollow core surrounded by microstructured cladding, is at the heart of the new sensing approach. Liquid goes through chambers in the fiber, and spectral shifts of maxima and minima in the transmission spectrum of HC-MOF are interpreted as signals about the chemical composition of the sample. With no need for an external cavity or interferometer, the sensing system is easy and inexpensive to produce.

The researchers tested its performance on the concentration of bovine serum albumin (BSA), which is commonly used in such experiments, dissolved in water and in a phosphate-buffered saline solution. The resolution they were able to show consistently in several experiments was equivalent to 1 gram of BSA in a liter of liquid, close to the accuracy of standard albumin tests and potentially meets clinical needs.

“Our concept can be considered a platform for intraoperative analysis of biomarkers of different types. For that, we need to test it on other bioanalytes and further modify the hollow core fiber to increase specificity. Future trials of these point-of-care devices will serve as the first step for realization of the true ‘bench-to-bedside’ approach,” Gorin notes.

“In-fiber multispectral optical sensing opens new horizons in fast, cheap, and reliable analysis of blood and other bodily liquids in real time that is important for timely diagnostics of various diseases and abnormal conditions,” Noskov adds.

The team plans to continue their research in increasing specificity as well as sensitivity of this approach. They are going to file a patent application and look for industrial partners and investors interested in developing clinical devices based on this type of sensors.

This work is a result of a collaboration between not only Skoltech and Tel Aviv university, but also other organizations, including Saratov State University, Moscow State University, Moscow Institute of Physics and Technology, Tomsk State University, RAS Institute of Precision Mechanics and Control, and Nanostructured Glass Technology, an industrial partner.

Source: Skoltech

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iPhone 12 Review | NDTV Gadgets 360

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Of the four members of the new iPhone 12 family, the base iPhone 12 might be easy to overlook. It isn’t a radically different size, it doesn’t have the highest-end camera system, and it is perhaps the most iterative in terms of updates in the new portfolio. This isn’t a simple upgrade to the iPhone 11 though; launching at a much higher starting price, it creates a new tier in Apple’s lineup. You could see it as a step up from the iPhone 12 mini, but much like there are two sizes of Apple Watch, the differences between these models are more to do with personal preference than capabilities.

Should you spend Rs. 10,000 more on the iPhone 12 than the iPhone 12 mini (Review)? Should this be your natural upgrade option if you’ve got an older model? What exactly does this model lack compared to the much more expensive, yet very similar iPhone 12 Pro (Review)? I have all these answers and much more.

iPhone 12 price and positioning in India

Prices have gone up across the industry thanks to a GST rate increase and fluctuations between the US Dollar and Indian Rupee. However, Apple has also decided to bump up the base price, leaving the iPhone 12 mini in the slot we expected the iPhone 12 to fill. That means you’ll have to spend a bit more than you might have anticipated if you don’t want the smaller model. The iPhone 12 price in India starts at Rs. 79,900 for 64GB, and goes up to Rs. 84,900 for 128GB and Rs. 94,900 for 256GB.

What’s interesting is that the iPhone 12 Pro price starts Rs. 40,000 higher at Rs. 1,19,000 (which is a much wider difference in India than elsewhere in the world, for reasons that Apple declined to clarify when asked). The iPhone 12 Pro has a stainless steel frame rather than aluminium, twice as much storage per tier, and a 2x optical telephoto camera plus a LiDAR sensor which has some applications for AR and low-light photography. It’s also capable of higher maximum screen brightness, 60fps Dolby Vision HDR video recording, Night mode portraits, and ProRAW photo capture. If none of these features matter to you, the much lower-priced iPhone 12 with exactly the same SoC, battery, and other camera hardware suddenly seems like a pretty compelling alternative.

Do keep in mind that none of the new iPhone 12 models come with a charger or headset in the box. You might want to pick up a MagSafe wireless charging pad, plus one of Apple’s own chargers if you don’t have a Type-C adapter lying around, and to get the fastest possible wireless charging. These, plus a case and maybe a pair of AirPods, will all add to the price you end up paying.

Battery life is better with the iPhone 12 than with the iPhone 12 mini


iPhone 12 design

We return to a completely flat front and back, as well as a flat frame running around the perimeter of the iPhone 12 family. This is somewhat like the iPhone 5 ­generation, but without even bevelled or chamfered edges meeting the display glass. If you choose one of the brighter colour options, you’ll see the metal frame around the edges of your device. That means the front and rear panels are more protected, but I suspected that the frame would likely get scuffed or dented without a case, and that’s exactly what happened within a week of using the iPhone 12.

Apple says its new Ceramic Shield material, used on the front, is four times more resistant to damage in case of drops, but that doesn’t mean it’s scratch-resistant. You also get an IP68 rating for water and dust resistance, and this phone did survive being tossed in a swimming pool and even being used to record video underwater for several minutes during the review period.

The lack of rounded edges means that the iPhone 12 does feel a little less comfortable in the hand and against the ear than the iPhone 11 (Review). However, it is considerably smaller in all dimensions, especially thickness, and also quite a bit lighter. At just 7.4mm thick and 162g, the differences are immediately noticeable. If you’re talking on the phone, playing games, shooting video, or even just scrolling through endless feeds, the iPhone 12 is an ergonomic improvement overall.

One-handed usage isn’t much of a problem, since thankfully the glass rear panel isn’t slippery. Without a case, the two camera rings on the rear do protrude quite a bit, which is a cause for concern. You get the usual power button on the right, and volume buttons plus mute switch on the left. There’s a Lightning connector on the bottom and invisible MagSafe magnetic ring on the back for Apple’s new line of wireless charging accessories. There’s a single Nano-SIM tray but you can use an eSIM if you need a second line.

iPhone 12 specifications and software

We’re now quite familiar with Apple’s A14 Bionic SoC, which can be found across the iPhone 12 lineup and in the new iPad Air (2020). It has two high-performance and four energy-efficient CPU cores, a quad-core GPU, next-gen “Neural Engine” AI logic, and more. Apple claims that this 5nm chip is not only the fastest current smartphone processor, but also incredibly power efficient. The big push with this generation is machine learning, which can be used to accelerate on-device AI to make apps and the UI itself more personal and secure.

One of the most noticeable upgrades that the iPhone 12 introduces is its screen. Apple has used almost exactly the same OLED panel on this device as on the iPhone 12 Pro, in stark contrast to previous generations in which lower-end models were saddled with noticeably lower-resolution LCD screens. This makes the iPhone 12 feel a lot more premium than its predecessors.

The 6.1-inch 1170×2532 HDR panel supports the wide P3 colour gamut and Apple’s True Tone ambient light adjustment feature. The notch at the top is pretty huge by today’s standards, and it’s definitely annoying when watching videos fullscreen, but it isn’t otherwise much of a problem if you’re used to using any fairly recent iPhone. A high refresh rate would have been nice, but that remains an advantage for the Android camp for now.

Apple doesn’t officially disclose things like battery capacity and amount of RAM for its products, but we know from third-party teardowns that the iPhone 12 has a 2,815mAh battery and 4GB of RAM. You can choose between 64GB, 128GB and 256GB of storage – considering the prices, the base model really should have had more, but cloud and streaming services these days have alleviated a lot of the pain of running out of space.

The entire iPhone 12 family supports sub-6GHz 5G, which isn’t a selling point now, but will hopefully be useful in India in the near future. There’s also Wi-Fi 6, Bluetooth 5, Ultra-wideband positioning, GPS, and NFC, though Apple restricts how some of these standards can be used.

iOS 14 runs exceptionally smoothly without a hint of hesitation. The UI is responsive and animations are super slick. Apps load quickly, even if they haven’t been used in a while. You do get more customisation options and built-in features (including some localised ones)  than with earlier versions but you still have to learn to do many things Apple’s way. Despite the high prices of iPhones, iOS 14’s stability and longevity, as well as its privacy features, do keep a lot of people within the fold.

Much of the appeal of iPhones is down to Apple’s various apps and services including iMessage, FaceTime, and iCloud. The company pushes its Apple Music, Arcade, and TV+ subscriptions heavily, and some of the notifications can get annoying. You can claim three free months of Apple Arcade and an entire year of TV+ with the purchase of any new iOS device, but iCloud storage is limited to 5GB without a paid subscription.

iphone 12 frame ndtv iphone

The aluminium frame is prone to scuffs and dents


iPhone 12 performance and battery life

It shouldn’t be any surprise that performance in everyday use was absolutely faultless. Everything from Face ID authentication to loading heavy games and switching between apps felt effortless. There isn’t much these days that really stresses out even mid-range phones, but the A14 Bionic still completely demolishes expectations in terms of responsiveness and fluidity.

That said, everything isn’t perfect. Even in normal use, I felt the back of the iPhone 12 get slightly warm. It wasn’t a problem, but it was noticeable. When pushing the A14 Bionic SoC to its limits in games and tests, the back and metal frame did get quite toasty, and this might be uncomfortable for some people over long stretches. A case might help mitigate this to some extent.

Benchmarks showed that Apple isn’t kidding when it talks about performance. AnTuTu reported a score of 5,68,462 while Geekbench 5’s single-core and multi-core scores were 1,563 and 3,675 respectively. As for graphics, every scene in GFXBench ran at 58fps or better, except for the highest-end Aztec Ruins (High Tier) test which managed 48.8fps. The new 3DMark Wild Life test also ran quite well, with 6660 points overall. In our iPhone 12 mini review, I pointed out that the Wild Life stress test revealed a drastic performance drop after just a few loops – the iPhone 12 did considerably better, but the stability score still dropped to 71.2 percent.

Call of Duty Mobile and Asphalt 9: Legends ran fine, aside from the body getting a bit warm. Casual games such as Alto’s Odyssey and Lara Croft Go were a lot of fun. You won’t have any trouble staying entertained, though you will have to supply your own Bluetooth earphones or recycle a headset with a Lightning connector from an older iPhone.

The display is bright, crisp, and engaging. Videos and games look great, apart from the large notch often getting in the way. Colours really pop in HDR videos, and this is one of the key areas in which the iPhone 12 is a significant upgrade over its predecessors. The stereo speakers produce surprisingly full and detailed sound, and although bass is weak there’s no distortion even at high volumes.

iphone 12 upright ndtv iphone

iOS 14 is more customisable than previous versions and has new privacy features


Battery life is not especially great but you can comfortably get through a full day and maybe have some power left over for the next morning. If you play games for an hour or so, stream lots of music, check social feeds and take lots of photos and videos, you’ll probably want to plug this phone in (or snap on a MagSafe pad) each night. The iPhone 12 lasted for a reasonable 14 hours, 32 minutes in our HD video loop test, beating the iPhone 12 mini by only a small margin and coming in slightly behind the iPhone 12 Pro with the same capacity battery. I wasn’t able to test charging speed in any meaningful way since Apple doesn’t bundle a charger anymore and buyers will use various adapters with different output ratings.

iPhone 12 cameras

You get the same arrangement of cameras as on the iPhone 11 – a 12-megapixel wide-angle primary camera and an additional 12-megapixel ultra-wide-angle one on the rear, plus another 12-megapixel sensor for the front camera. Other than generational improvements, the main difference in specifications is in the aperture of the primary camera, which is now f/1.6 for better low-light shots. On the software side, you can now use Night mode and Deep Fusion on all three cameras, and you can record Dolby Vision HDR video at up to 30fps.

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iPhone 12 daytime photo sample (cropped)


The main benefits are better performance and more versatility in low light. Most of Apple’s camera tricks work in the background – you don’t get to choose when Deep Fusion is active, but it will combine multiple exposures using what Apple calls “computational photography” to produce a single, well-exposed frame. Night mode isn’t a separate mode that you need to select; it just kicks in when needed. This is exactly the same experience you’ll have with the iPhone 12 mini, and unsurprisingly, results are pretty much exactly the same with both phones.

Daytime shots came out looking crisp and bright, with colours that were vibrant but not oversaturated, and decent amounts of detail even in distant objects. The ultra-wide-angle camera does a great job, and photos have the same general tone and minimal distortion at the edges, though definition is noticeably weaker. Close-ups have excellent natural-looking depth of field. The iPhone 12’s primary camera’s biggest strength seems to be its ability to reproduce extremely fine detail in close-ups, even when there are complex exposures to deal with.

iPhone 12 Review NDTV Gadgets 360

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iPhone 12 daytime photo sample (top: wide-angle; bottom: ultra-wide-angle)



Portrait mode works with humans and pets, and the background is aesthetically de-emphasised. It is s sometimes a bit fussy when locking on to a subject though, and edge detection isn’t great with irregular objects such as flowers. You can adjust the background blur and portrait lighting effects after taking a shot. Shooting ordinary close-ups is effortless in contrast, and far more flexible in terms of framing, but you don’t get the same lush effect and tweaking options.

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iPhone 12 daytime close-up photo sample


As for low-light shots, the iPhone 12 truly excelled, revealing details in landscapes that were completely invisible to the naked eye. With barely any ambient light around, this phone was able to reveal sharp detail in close-ups and surprising contrast in landscapes. The default delay is 2-3 seconds but you can push this up to 29 seconds, which is only advisable if you’re using a tripod. On a moonless night, I was able to capture stars as actual points, and not just blotches against the black sky.

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iPhone 12 Night mode photo sample

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iPhone 12 Night mode photo sample (using tripod)


Video is recorded in HDR by default, and you’ll need to visit the main iOS Settings app to override this. It comes out looking smooth and vibrant at 1080p as well as 4K, with very little jerkiness thanks to the primary camera’s optical stabilisation. You can get pretty good results with the wide-angle camera as well, in the daytime and at night.

Selfies are also sharp and detailed, and Night mode helps you capture usable (though slightly grainy) shots even in dark corners with very little light around.

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iPhone 12 selfie samples (top: daytime portrait; bottom: Night mode)




The iPhone 12 is a solid, competent phone but it is also very expensive. Along with the iPhone 12 mini, it’s clearly positioned as a premium option, with its slick new body, excellent high-resolution OLED screen, and flexible cameras. The choice between the two siblings will come down to personal preference in terms of handling and screen size, but you should also consider the difference in battery life.

If you’re currently using an iPhone 11 or iPhone XR, chances are you won’t gain much by upgrading at the moment. For users of older models who have been waiting for a good reason to upgrade and intend to hold on to their purchase for at least three years, both the iPhone 12 and iPhone 12 mini will feel fresh and offer great performance for at least that long.

You should also consider that you get nearly all the capabilities of the much more expensive iPhone 12 Pro at a far lower price. Unless money is no object or you’re very serious about photography and video recording, the iPhone 12 should serve all your needs.

Last year’s iPhone 11 and even the two-year-old iPhone XR still selling for considerably less. These are actually the strongest competitors to the iPhone 12, especially if you consider value for money (and that’s even more apparent when they go on sale). Sure, they don’t have all the latest and greatest features, but they do most of what the iPhone 12 does, and they’ll receive regular software updates for at least a few more years.

Will iPhone 12 mini become the affordable iPhone we’ve been waiting for? We discussed this on Orbital, our weekly technology podcast, which you can subscribe to via Apple Podcasts, Google Podcasts, or RSS, download the episode, or just hit the play button below.

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