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The SpaceX Crew Dragon spacecraft shoved off from the International Space Station on Saturday with two US astronauts on board, beginning their journey back to Earth despite a storm threatening Florida. NASA footage showed the capsule drifting slowly away from the ISS in the darkness of space, ending a two month stay for the first US astronauts to reach the orbiting lab on an American spacecraft in nearly a decade.

“And they are off!” the US space agency tweeted, with Doug Hurley and Bob Behnken set to splash down Sunday.

“(They) will spend one more night in space prior to returning to their homeland, Earth,” NASA tweeted.

Their proposed splash-down sites are off the coast of western Florida’s panhandle, while tropical storm Isaias is headed toward the state’s east coast.

NASA opted to go ahead with bringing the pair home despite the threat of Isaias, which was downgraded to a tropical storm from a hurricane on Saturday.

The agency later added the capsule was confirmed to be “on a safe trajectory.”

“Now is the entry, descent and splashdown phase after we undock, hopefully a little bit later today,” Hurley said in a farewell ceremony aboard the ISS that was broadcast on NASA TV.

“The teams are working really hard, especially with the dynamics of the weather over the next few days around Florida,” he said.

Earlier, during the ISS ceremony, Behnken said that “the hardest part was getting us launched. But the most important part is bringing us home.”

Addressing his son and Hurley’s son, he held up a toy dinosaur that the children chose to send on the mission and said: “Tremor The Apatosaurus is headed home soon and he’ll be with your dads.”

Behnken later tweeted: “All my bags are packed, I’m ready to go.”

‘Exciting day’

Mission chief Chris Cassidy called it an “exciting day” and hailed the importance of having a new means to transport astronauts.

The mission, which blasted off May 30, marked the first time a crewed spaceship had launched into orbit from American soil since 2011 when the space shuttle program ended.

It was also the first time a private company has flown to the ISS carrying astronauts.

The US has paid SpaceX and aerospace giant Boeing a total of about $7 billion for their “space taxi” contracts.

But Boeing’s program has floundered badly after a failed test run late last year, which left SpaceX, a company founded only in 2002, as clear frontrunner.

For the past nine years, US astronauts traveled exclusively on Russian Soyuz rockets, for a price of around $80 million per seat.

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Realme Q Series Phone Allegedly Spotted on TENAA, Key Specifications Tipped

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Realme Q series seem to be getting a new smartphone and it allegedly been spotted on TENAA, offering a glimpse of the possible specifications. A Realme smartphone with model number RMX2117 was spotted on the regulator’s website and it is being speculated that the phone could be a part of the company’s Q series that already includes one phone. The TENAA listing shows the phone sporting a 6.5-inch display and powered by an octa-core SoC clocked at 2.4GHz. The listing also hints that the phone may carry up to 8GB of RAM and up to 256GB of onboard storage. Realme hasn’t officially confirmed any of the specifications.

As per the listing on TENAA, the smartphone with model number RMX2117 sports a 6.5-inch full-HD+ (1,080×2,400 pixels) display with a 20:9 aspect ratio. Allegedly belonging to the rumoured Realme Q series, the smartphone supports 5G and is powered by an octa-core SoC clocked at 2.4GHz.

The Realme Q series phone may be launched in China in three RAM options – 4GB, 6GB, and 8GB, that may be coupled with three inbuilt storage configurations – 64GB, 128GB, and 256GB. The listing also shows a microSD card slot for storage expansion. It may be launched in four colour options – Black, Blue, Gray, and Silver.

The phone is seen featuring a rectangular camera module that includes a 48-megapixel primary sensor, an 8-megapixel snapper, and a 2-megapixel shooter. For selfies and video calls, the phone features a 16-megapixel camera at the front. The Realme RMX2117 smartphone packs a 4,900mAh battery. The handset runs on Android 10 and features a side-mounted fingerprint scanner. The smartphone measures 162.2 x 75.1 x 9.1mm and weighs 194 grams.

The development comes a week after Realme vice president Xu Qi Chase teased the arrival of a new series, including the Q series, V series, and X series, with in a poster. Chase noted that the upcoming phone will be powered by a 5nm flagship chipset.


Redmi Note 8 or Realme 5s: Which is the best phone under Rs. 10,000 in India right now? We discussed this on Orbital, our weekly technology podcast, which you can subscribe to via Apple Podcasts or RSS, download the episode, or just hit the play button below.

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How to remove the 3D Objects folder from File Explorer in Windows 10

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The 3D Objects folder is not useful for many users but removing it from File Explorer in Windows 10 requires a tweak of the Registry File. We show you how.

Image: scyther5, Getty Images/iStockphoto

In addition to the traditional Paint application, which has been a part of Windows since its beginning, Microsoft has also added Paint 3D to its list of standard Windows 10 applications. When combined with a touch display and a stylus or pen, Paint 3D can be a powerful tool for creating three-dimensional objects, a feature many artists and designers find useful.

SEE: 30 Excel tips you need to know (TechRepublic Premium)

However, if you are not inclined to use Paint 3D, you may find the prominence of a 3D Objects folder, and possibly several other folders, on the This PC screen of File Explorer obtrusive and unnecessary. Unfortunately, you cannot remove those folders from File Explorer with a simple change to default settings. That procedure requires an edit of the Windows 10 Registry File.

This how-to tutorial shows you how to remove the 3D Objects folder, and other folders, from the This PC screen of the Windows 10 File Explorer.

How to remove 3D Objects folder from File Explorer

Disclaimer: Editing the Windows Registry file is a serious undertaking. A corrupted Windows Registry file could render your computer inoperable, requiring a reinstallation of the Windows 10 operating system and potential loss of data. Back up the Windows 10 Registry file and create a valid restore point before you proceed.

To get a better idea of what we are talking about, open File Explorer in Windows 10 and then navigate to the This PC screen, as shown in Figure A. Take note of the default listing of folders in the right-hand window.

Figure A

a-remove-folders-file-explorer.jpg

We are going to concentrate our efforts on the 3D Objects folder, but this technique will work for any of the default folders listed in that section of File Explorer, if you know the code. Further, if you are running the 64-bit version of Windows 10, you will have to perform two edits.

Type “regedit” into the search box on the Windows 10 desktop and select the appropriate result to start the Registry Editor application. As shown in Figure B, navigate to this key (it’s a deep dive):

HKEY_LOCAL_MACHINESOFTWAREMicrosoftWindowsCurrentVersionExplorerMyComputerNameSpace

Figure B

b-remove-folders-file-explorer.jpg

To complicate matters, the subkeys in the NameSpace section are coded, so you have to carefully choose the key with this code (on my computer, it was in the second position, see Figure C):

{0DB7E03F-FC29-4DC6-9020-FF41B59E513A}

Figure C

c-remove-folders-file-explorer.jpg

Right-click the key and select “Delete” from the context menu and confirm your action.

If you are running the 32-bit version of Windows 10, you have completed the procedure, however, if you are running the 64-bit version, you will have to perform a second edit. As shown in Figure D, navigate to this key:

HKEY_LOCAL_MACHINESOFTWAREWow6432NodeMicrosoftWindowsCurrentVersionExplorerMyComputerNameSpace

Figure D

d-remove-folders-file-explorer.jpg

As before, locate this coded key in the NameSpace folder, as shown in Figure E:

{0DB7E03F-FC29-4DC6-9020-FF41B59E513A}

Figure E

e-remove-folders-file-explorer.jpg

Right-click the key and select “Delete” from the context menu and then confirm your selection to complete the process. Exit out of the Registry File editor. The change should take effect the next time you open File Explorer.

The 3D Objects folder is located in the Users folder and will still be there after implementing this procedure, but it will no longer be displayed so prominently in the This PC section of File Explorer, as shown in Figure F.

Figure F

f-remove-folders-file-explorer.jpg

To restore the 3D Objects folder to File Explorer, add the coded key back into the two NameSpace Folders using the Registry File Editor.

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Twist on CRISPR Gene Editing Treats Adult-Onset Muscular Dystrophy in Mice

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Myotonic dystrophy type I is the most common type of adult-onset muscular dystrophy. People with the condition inherit repeated DNA segments that lead to the toxic buildup of repetitive RNA, the messenger that carries a gene’s recipe to the cell’s protein-making machinery. As a result, people born with myotonic dystrophy experience progressive muscle wasting and weakness and a wide variety of other debilitating symptoms.

CRISPR-Cas9 is a technique increasingly used in efforts to correct the genetic (DNA) defects that cause a variety of diseases. A few years ago, University of California San Diego School of Medicine researchers redirected the technique to instead modify RNA in a method they call RNA-targeting Cas9 (RCas9).

Twist on CRISPR Gene Editing Treats Adult Onset Muscular Dystrophy in

Green muscle fibers with RCas9 (the therapeutic candidate for myotonic dystrophy) have eliminated their toxic RNA (red), whereas fibers lacking RCas9 (dark) have persisting toxic RNA (red). Credit: UC San Diego

In a new study published in Nature Biomedical Engineering, the team demonstrates that one dose of RCas9 gene therapy can chew up toxic RNA and almost completely reverse symptoms in a mouse model of myotonic dystrophy.

“Many other severe neuromuscular diseases, such as Huntington’s and ALS, are also caused by similar RNA buildup,” said senior author Gene Yeo, PhD, professor of cellular and molecular medicine at UC San Diego School of Medicine. “There are no cures for these diseases.” Yeo led the study with collaborators at Locanabio, Inc. and the University of Florida.

Normally, CRISPR-Cas9 works by directing an enzyme called Cas9 to cut a specific target gene (DNA), thereby allowing researchers to inactivate or replace the gene. RCas9 works similarly, but Cas9 is guided to an RNA molecule instead of DNA.

In a 2016 study, Yeo’s team demonstrated that RCas9 worked by using it to track RNA in live cells. In a 2017 study in lab models and patient-derived cells, the researchers used RCas9 to eliminate 95 percent of the aberrant RNA linked to myotonic dystrophy type 1 and type 2, one type of ALS and Huntington’s disease.

The current study advances RCas9 therapy further, reversing myotonic dystrophy type 1 in a living organism: a mouse model of the disease.

The approach is a type of gene therapy. The team packaged RCas9 in a non-infectious virus, which is needed to deliver the RNA-chewing enzyme inside cells. They gave the mice a single dose of the therapy or a mock treatment.

RCas9 reduced aberrant RNA repeats by more than 50 percent, varying a bit depending on the tissue, and the treated myotonic dystrophy mice became essentially indistinguishable from healthy mice.

Initially, the team was worried that the RCas9 proteins, which are derived from bacteria, might cause an immune reaction in the mice and be rapidly cleared away. So they tried suppressing the mice’s immune systems briefly during treatment. As a result, they were surprised and pleased to discover that they prevented immune reaction and clearance, leaving the viral vehicle and its RCas9 cargo to persist, and get the job done. What’s more, they did not see signs of muscle damage. In contrast, they saw an increase in the activity of genes involved in new muscle formation.

“This opens up the floodgates to start testing RNA-targeting CRISPR-Cas9 as a potential approach to treat other human genetic diseases — there are at least 20 caused by buildup of repetitive RNAs,” Yeo said.

It remains to be seen if RCas9-based therapies will work in humans, or if they might cause deleterious side effects, such as eliciting an undesired immune reaction. Preclinical studies such as this one will help the team work out potential toxicities and evaluate long-term exposure.

In 2017, Yeo co-founded a company called Locanabio to accelerate the development of RNA-targeting CRISPR-Cas9 through preclinical testing and into clinical trials for the treatment of myotonic dystrophy and potentially other diseases.

Source: UC San Diego




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