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People who maintain cardiovascular fitness as they age exhibit an onset of degeneration and age-related disease that takes place more slowly than that of their peers. This includes a much lower risk of dementia, as illustrated by the study data noted here, indicating the strong influence of the cardiovascular system on brain function.

Better Cardiovascular Fitness in Mid Life Correlates with Lower Risk of

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Firstly, the brain is an energy-hungry organ, and worse circulation leads to worse function quite directly. Separately, cardiovascular fitness tends to correlate with a lesser degree of hypertension with age. The raised blood pressure of hypertension causes damage to brain tissue and vessels in the brain, and a consistently lower level that damage makes a noteworthy difference over time.

Distinctly again, the exercise needed to maintain physical fitness produces greater cell maintenance activities, leading to a slower accumulation of many forms of cell and tissue damage that contribute to to onset of dementia.

Very few studies have explored the patterns of cardiovascular health (CVH) metrics in midlife and late life in relation to risk of dementia. We examined the associations of composite CVH metrics from midlife to late life with risk of incident dementia. This cohort study included 1,449 participants from the Finnish Cardiovascular Risk Factors, Aging, and Dementia (CAIDE) study, who were followed from midlife (baseline from 1972 to 1987; mean age 50.4 years; 62.1% female) to late life (1998), and then 744 dementia-free survivors were followed further into late life (2005 to 2008). We defined and scored global CVH metrics based on 6 of the 7 components (i.e., smoking, physical activity, and body mass index [BMI] as behavioral CVH metrics; fasting plasma glucose, total cholesterol, and blood pressure as biological CVH metrics) following the modified American Heart Association (AHA)’s recommendations. Then, the composite global, behavioral, and biological CVH metrics were categorized into poor, intermediate, and ideal levels. Dementia was diagnosed following the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) criteria.

During the follow-up examinations, dementia was diagnosed in 61 persons in 1998 and additional 47 persons in 2005 to 2008. The fully adjusted hazard ratio (HR) of dementia was 0.71 and 0.52 for midlife intermediate and ideal levels (versus poor level) of global CVH metrics, respectively; the corresponding figures for late-life global CVH metrics were 0.60 and 0.91 . Compared with poor global CVH metrics in both midlife and late life, the fully adjusted HR of dementia was 0.25 for people with intermediate global CVH metrics in both midlife and late life and 0.14 for those with midlife ideal and late-life intermediate global CVH metrics. Having an intermediate or ideal level of behavioral CVH in both midlife and late life (versus poor level in both midlife and late life) was significantly associated with a lower dementia risk, whereas people with midlife intermediate and late-life ideal biological CVH metrics had a significantly increased risk of dementia.

In this study, we observed that having the ideal CVH metrics, and ideal behavioral CVH metrics in particular, from midlife onwards is associated with a reduced risk of dementia as compared with people having poor CVH metrics. Maintaining life-long health behaviors may be crucial to reduce late-life risk of dementia.

Link: https://doi.org/10.1371/journal.pmed.1003474

Source: Fight Aging!




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Proteomic analysis reveals when and how which proteins are degraded in cancer cells by Autophagy pathways

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Beyond maintenance of organelle and protein homeostasis, Autophagy also called “self-eating”, plays a major role in cellular survival as fundamental stress and adaptation response, in particular during diverse starvation conditions. There are, however, multiple different autophagic pathways in mammalian cells that is known to contribute for degrading different cellular components. Which of these autophagy pathways are responsible for degrading which proteins and when this occurs has remained undefined.

Thousands of proteins can be degraded in cancer cells through autophagy pathways

The research team at Karolinska Institutet, under the direction of Associate Professor Helin Norberg, has previously provided new insights into this by characterizing proteins degraded by different autophagic pathways in cancer cells (Autophagy, 2019). In the new study (Autophagy, 2021), they now reveal how and which proteins are degraded, and that it occurs in an orderly sequential manner, which was found to be dependent on the function the protein has in cancer cells.

“An important aspect of these findings is that the majority of the identified proteins display dominant oncogenic pro-survival activities, who’s pathogenic stabilization effectively sustains tumour progression and dissemination. Since our finding outline how these proteins can be degraded, our discoveries lay the basis for understanding the mechanisms of how oncoproteins can be “eaten up” by the cells. Most importantly, when we know how, when and which cancer-promoting proteins can be degraded, we can also start to design new strategies that could selectively promote their degradation-specific mechanisms for the development of novel anti-cancer approaches, says Helin Norberg, Docent at the Department of Physiology and Pharmacology.”

Source: Karolinska Institutet



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Flipkart SmartPack Offers 100% Moneyback on Top Smartphones in India

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Buying a new smartphone is a special feeling. But when you consider the amount of money you have to spend on a new phone, and on top of it all those Online Subscription Services, you have to think again. What if there was a way you could get 100% moneyback on the smartphone of your choice? What if you had to pay only for the online services you use?

Flipkart has come up with an industry-first innovative solution that brings 100% moneyback when you buy a new smartphone from popular brands such as Realme, Poco, Samsung, Redmi, Motorola, Infinix, Oppo, and others. You get the entire amount directly in your bank account after 12/18 months. Sounds too good to be true? Well, you better believe it.

What is Flipkart SmartPack?

Flipkart SmartPack is the Smartest way to buy a Smartphone of your choice. You get 100% moneyback along with access to some of the best online services which you’d normally have to pay for, besides spending money on a new smartphone. Flipkart SmartPack, will make it easier and more affordable for Indian smartphone users to buy a new smartphone every year.

What Does Flipkart SmartPack Offer?

The Flipkart SmartPack plans offer benefits of multiple online services including Disney+ Hotstar VIP, SonyLiv, Zee5, Zomato Pro, Cult.fit Live, Practo, Gaana, etc. Now you don’t have to buy individual subscription packs for each of these services. The feature gives you moneyback directly into your bank account, and not vouchers or points so that you can simply use the money to buy a new smartphone next year.

How to get 100% moneyback using Flipkart SmartPack?

Here are the simple steps you can follow to avail Flipkart SmartPack:

1. Choose your favourite smartphone on Flipkart
2. Pick a Flipkart SmartPack of your choice. You can choose from 12 months or 18 months duration.
3. Pay for your smartphone upfront, and you can pay for your Flipkart SmartPack every month. 4. Return your smartphone after 12 or 18 months in any working condition*, and Get upto 100% Moneyback in your bank account.

That’s it! Flipkart SmartPack is perfect for those who wish to buy the perfect smartphone for themselves, from a top mobile brand, and don’t want to pay the full amount. This way you only end up paying for a host of online services that you normally pay extra. Customers can also choose to pay the entire amount for the smartphone upfront or use the available no-cost EMI payment options.

The innovative offering lets you buy a smartphone, and get 100 percent moneyback directly in your bank account after a year. This way you only end up paying for the online services that you use. Customers can return the smartphone in any working condition, provided it turns on and the IMEI number is visible on the screen after 12/18 months.

Besides 100% moneyback, consumers will also get access to complete mobile protection plans that offer protection against screen damage, liquid damage, and other accidental covers. There is no better way to buy a new smartphone in India than the Flipkart SmartPack way. With Flipkart’s trusted network of sellers and an innovative offering like Flipkart SmartPack, you’re assured a Great Smartphone buying experience no matter which phone you buy.

Flipkart SmartPack is now available in India. For more details, visit this page.

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New sodium oxide paves way for advanced sodium-ion batteries

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Skoltech researchers and their collaborators from France, the US, Switzerland, and Australia were able to create and describe a mixed Na(Li1/3Mn2/3)O2 oxide that holds promise as a cathode material for sodium-ion batteries, which can one day complement or even replace lithium-ion batteries. The paper was published in the journal Nature Materials.

New sodium oxide paves way for advanced sodium ion batteries

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Lithium-ion batteries are powering the modern world of consumer devices and driving a revolution in electric transportation. But since lithium is rather rare and challenging to extract from an environmental standpoint, researchers and engineers have been looking for more sustainable and cost-effective alternatives for quite some time now.

One option is sodium-ion technology, as sodium is much more abundant than lithium. Na-ion batteries, however, still struggle to provide high energy density and cycling stability. Thus, the search for an optimal design for Na-based cathodes is underway in laboratories across the world.

Skoltech Professor and Director of the Center for Energy Science and Technology Artem Abakumov and PhD student Anatolii Morozov were part of an international team that studied the compound Na(Li1/3Mn2/3)O2, patented by Renault. This compound showed promise as a cathode material with high energy density, no voltage fade over multiple charge cycles, and moisture stability.

“We have performed all the transmission electron microscopy (TEM) studies using the equipment at Advanced Imaging Core Facility of Skoltech. We investigated the crystal structure of Na(Li1/3Mn2/3)O2 by electron diffraction and directly visualized it with atomic resolution scanning transmission electron microscopy techniques. Furthermore, we investigated this material at various states of charge by TEM, which allowed to trace the evolution of its crystal structure during the electrochemical cycling,” Morozov says.

Among other things, the team found that the new compound possesses a reversible specific discharge capacity of 190 mAh/g, which is relatively high values for sodium-ion battery cathode materials. According to Morozov, it also demonstrates a good capacity retention and moisture resistance, which is unusual for compounds of this kind. “Moreover, no significant voltage fade was observed during prolonged cycling of Na(Li1/3Mn2/3)O2; it’s a key drawback of similar Li-rich layered cathode materials,” the Skoltech PhD student says.

However, despite these promising properties, Na(Li1/3Mn2/3)O2 exhibits a large voltage hysteresis during charge and discharge, which leads to a decrease in the energy efficiency of the cathode material and can become an obstacle in commercial implementation. “We assume that the appearance of a large voltage hysteresis is associated with the migration of Mn within the structure. Thus, in the future it is necessary to develop a model for cation ordering and find a path to control it to overcome this issue,” Anatolii Morozov notes.

“The team used Titan Themis Z electron microscope at our Advanced Imaging Core Facility (AICF), which allows to visualize single atoms in the crystal lattice of a material and study its structure and how it relates to the properties of that material. But top-level equipment is necessary but not enough for impressive scientific results; we see the skills of our staff scientists and students as crucial and invest a lot in the development of those skills. With Prof. Abakumov being a Research Advisor of AICF, close scientific collaboration between our team and Skoltech scientists becomes possible. This gives Skoltech competitive advantage when it comes to the implementation of complex research projects or development of unique technologies.” notes Yaroslava Shakhova, Head of the Skoltech Advanced Imaging Core Facility.

Other organizations involved in this research include Chimie du Solide-Energie, Collège de France; Sorbonne Université; Renault Technocentre; Réseau sur le Stockage Electrochimique de l’Energie (RS2E); Université d’Orléans; Université de Pau et des Pays de l’Adour; Lawrence Berkeley National Laboratory; Paul Scherrer Institute; The University of Sydney; Australian Centre for Neutron Scattering, Australian Nuclear Science and Technology Organisation; University of Illinois at Chicago; University of Montpellier.

Source: Skoltech




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